The E-Class is Mercedes-Benz's mid-sized premium sedan. It slots neatly between the smaller C-Class and the big S-Class. The model lineup begins with the E320 CDI sedan, which is powered by a 201-hp, 3.2L inline six-cylinder diesel engine. This model provides compact-car-like mileage of 27 mpg in the city and 37 on the highway in a full-size, luxury car package. The diesel engine features a substantial 369 lb.-ft. of torque that is routed to the rear wheels through a five-speed automatic transmission. Pitted against such rivals as the Audi A6, BMW 5-Series and Lexus GS, the E-Class sedan and wagon offer a combination of room, luxury, power and affordability (by Mercedes' standards at least). With the choice of V6 or V8 powerplants, rear-wheel or all-wheel drive and a host of luxury features, there is an E-class to suit just about everyone who can afford the $50K plus price tag.

The A new V6 engine signals the arrival of the E350 model for 2006. The E-Class line offers diesel- and gas-powered engines and rear- or all-wheel drive. E350s have a 268-hp 3.5-liter V6 and replace E320 models, which had a 221-hp 3.2 V6. The E320 CDI has a 201-hp 6-cyl turbodiesel. E500s have a 302-hp V8. High-performance E55s have a supercharged 469-hp V8. Front and rear side airbags, curtain side airbags with rollover sensors, and Mercedes' Tele Aid assistance are standard. Options include steering-linked bi-xenon headlamps and adaptive cruise control. Also available: voice-activated cell phone, navigation system, heated/cooled front seats, and massaging front seats. Mercedes' optional Keyless Go system uses a pocket transmitter for unlocking and engine starting. Rear obstacle detection is available for sedans, so is Mercedes' full-length Panorama glass sunroof with a power tilt/slide panel above the front seats. The E55 has sport suspension, exhaust, and seats. The CDI is a sedan; all others are available as sedans or wagons. Mercedes' 4Matic AWD is standard on E500 wagons and available in place of rear-drive on other models except the CDI and E55. CDI, E55, and 4Matic versions have a 5-speed automatic transmission. All other models have a 7-speed automatic. Both transmissions have a manual shift gate; E55 adds manual-shift steering wheel buttons. Emissions regulations prevent the CDI's sale in California and four northeastern states. ABS and traction/antiskid control are standard. Standard on E55 and E500 models, optional on E350s is an air suspension with driver-adjustable shock absorbers.